| Объем | 100 мкл |
| Синонимы | CDC like kinase 1, CLK, CLK1, Dual specificity protein kinase CLK1, EC 2.7.1.112 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P49759 |
| Иммуноген | Synthesized peptide derived from internal of human CLK1. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 |
| Примечание | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<br/><br/>Johnson K.W., J. Biol. Chem. 266:3402-3407(1991).<br/>Hanes J.J., J. Mol. Biol. 244:665-672(1994).<br/>Olsen J.V., Cell 127:635-648(2006). |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 293 cells, using CLK1 antibody.
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Immunofluorescence analysis of HUVEC cells, using CLK1 antibody.
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Наименование: CLK1 Antibody.