EIF4EBP1 (Ab-69) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | 4EBP1, EIF4EBP1, P/OKCL.6, PHAS-1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q13541 | | Иммуноген | Synthesized non-phosphopeptide derived from human 4E-BP1 around the phosphorylation site of threonine 70 (A-K-T-P-P). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<br/><br/>Anne-Claude Gingras, Genes & Dev., Jun 1999, 13: 1422. <br/>Guangming Liu, J. Biol. Chem., Mar 2002, 277: 8810 - 8816. <br/>Ya-Ping Jiang, J. Biol. Chem., Mar 2001, 276: 10943 - 10951. <br/>Anne-Claude Gingras, Genes & Dev., Feb 1998, 12: 502. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from COS7 cells, treated with EGF (200ng/ml, 30mins), using 4E-BP1 (Ab-69) antibody.
 | Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using 4E-BP1 (Ab-69) antibody.
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Наименование: EIF4EBP1 (Ab-69) Antibody.