COPS2 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | ALIEN, COP9 constitutive photomorphogenic homolog subunit 2, COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis), COP9 signalosome complex subunit 2, CSN2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P61201 | | Иммуноген | Synthesized peptide derived from internal of human COPS2. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 | | Примечание | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.<br/><br/>Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).<br/>Lee J.W., Mol. Endocrinol. 9:243-254(1995).<br/>Dressel U., Mol. Cell. Biol. 19:3383-3394(1999).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from COS-7 cells and COLO205 cells, using COPS2 antibody.
 | Immunofluorescence analysis of A549 cells, using COPS2 antibody.
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Наименование: COPS2 Antibody.