CSK AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Tyrosine-protein kinase CSK, EC 2.7.10.2, C-SRC kinase, Protein-tyrosine kinase CYL, CSK | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P41240 | | Иммуноген | Synthesized peptide derived from internal of human CSK. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 | | Примечание | Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.<br/><br/>Partanen J., Oncogene 6:2013-2018(1991).<br/>Braeuninger A., Proc. Natl. Acad. Sci. U.S.A. 88:10411-10415(1991).<br/>Brauninger A., Gene 110:205-211(1992).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Jurkat cells, using CSK antibody.
 | Immunofluorescence analysis of A549 cells, using CSK antibody.
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Наименование: CSK Antibody.