CUL2 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | cullin 2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q13617 | | Иммуноген | Synthetic peptide of human CUL2 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB,ELISA:1:2000-1:5000, WB:1:500-1:2000 | | Примечание | Human CUL2 is an ortholog of nematode cul2. Michel and Xiong (1998) identified human CUL2 cDNAs and reported that the predicted protein is 745 amino acids long.Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen affinity purification | | Области исследований | Cancer,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Gel: 6%SDS-PAGE,Lysate: 40 ?g,,Primary antibody: CSB-PA788466(CUL2 Antibody) at dilution 1/440 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 3 minutes
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Наименование: CUL2 Antibody.