DDB1 Monoclonal AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Damage specific DNA binding protein 1, Damage-specific DNA-binding protein 1, DDB 1, DDB p127 subunit, Ddb1, DDB1_HUMAN, DDBa, DNA damage binding protein 1, DNA damage-binding protein 1, DNA damage-binding protein a, HBV X-associated protein 1, | | Видовая специфичность | Human | | Uniport ID | Q16531 | | Иммуноген | Purified recombinant human DDB1 protein fragments expressed in E.coli. | | Источник | Mouse | | Видовая специфичность 1 | Human,Mouse,Rat,Monkey | | Применение | ELISA,WB,Recommended dilution:WB:1:500-1:5000 | | Примечание | Required for DNA repair.Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex).The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair.The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD),6-4 photoproducts (6-4 PP),apurinic sites and short mismatches.Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1.DCX(DDB2) (also known as DDB1-CUL4-ROC1,CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A,histone H3 and histone H4 at sites of UV-induced DNA damage.The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair.DCX(DDB2) also ubiquitinates XPC,which may enhance DNA-binding by XPC and promote NER.DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication.DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR).May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2. | | Изотип | IgG2b | | Метод очистки | Affinity purified | | Коньюгат | Non-conjugated | | Буффер | Ascites | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Области исследований | Epigenetics and Nuclear Signaling | | Станица на сайте производителя | ссылка | | | |
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Наименование: DDB1 Monoclonal Antibody.