DISC1 AntibodyСпецификация| Объем | 50 мкг | | Синонимы | Disrupted in schizophrenia 1 protein, DISC1, KIAA0457 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9NRI5 | | Иммуноген | Recombinant Human Disrupted in schizophrenia 1 protein (99-325AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IF, Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:200 | | Примечание | Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Disrupted in schizophrenia 1 protein | | Области исследований | Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate, Hela whole cell lysate
All lanes: DISC1 antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 94, 92, 74, 39, 83, 63, 61, 76, 73, 38, 22 kDa
Observed band size: 94, 92, 38 kDa
 | Immunofluorescent analysis of Hela cells using CSB-PA889093LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Наименование: DISC1 Antibody.