| Объем | 100 мкл |
| Синонимы | Forkhead box protein N4, FOXN4, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q96NZ1 |
| Иммуноген | Synthesized peptide derived from internal of human FOXN4. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development By similarity.<br/><br/>Scherer S.E., Nature 440:346-351(2006).<br/>Danilova N., Brain Res. Dev. Brain Res. 153:115-119(2004).<br/>Ota T., Nat. Genet. 36:40-45(2004).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling,Developmental biology |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from LOVO cells, using FOXN4 antibody.
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Наименование: FOXN4 Antibody.