EGFR (Ab-1110) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Receptor tyrosine-protein kinase ErbB-1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P00533 | | Иммуноген | Peptide sequence around aa. 1108~1112 (P-V-Y-H-N) derived from Human EGFR. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.<br/><br/>Kaisa Erjala, et al. (2006) Clin. Cancer Res Jul 2006, 12: 4103 - 4111. <br/>Judit Anido, et al. (2003) Clin. Cancer Res , 9: 1274. <br/>Julian Andreev, et al. (2001) J. Biol. Chem , 276: 20130 - 20135. <br/>Suil Kim, et al. (2002) Am J Physiol Lung Cell Mol Physiol, 283: 67. <br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cancer,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HUVEC and A431 cells using EGFR(Ab-1110) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EGFR(Ab-1110) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: EGFR (Ab-1110) Antibody.