| Объем | 100 мкл |
| Синонимы | Glutamate [NMDA] receptor subunit epsilon 2 precursor, GRIN2B, hNR3, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subtype 2B |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q13224 |
| Иммуноген | Synthesized non-phosphopeptide derived from human GRIN2B around the phosphorylation site of serine 1303 (Q-H-S(p)-Y-D). |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death By similarity.<br/><br/>Lasky L.A., J. Biol. Chem. 275:21477-21485(2000).<br/>Mandich P., Neurosci. Lett. 239:49-53(1997).<br/>Ajmar F., Genomics 22:216-218(1994).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Neuroscience |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from 3T3 cells (Lane 2), using GRIN2B (Ab-1303) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: GRIN2B (Ab-1303) Antibody.