HSD17B10 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | EC 1.1.1.35, 3-hydroxyacyl-CoA dehydrogenase type II, Type II HADH, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, EC 1.1.1.178 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q99714 | | Иммуноген | Synthesized peptide derived from human ERAB. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).<br/><br/>Shi Du Yan, J. Biol. Chem., Jan 1999, 274: 2145.<br/>C Hansis, Eur. J. Biochem., Nov 1998, 258: 53.<br/>Xue-Ying He, Eur. J. Biochem., Sep 2001, 268: 4899.<br/>Natalie A. Sims, J. Clin. Invest., May 2003, 111: 1319.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Neuroscience,Tags & Cell Markers,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human brain tissue using ERAB antibody.
 | Western blot analysis of extracts from LOVO cells, using ERAB antibody.
 | Western blot analysis of extracts from A549 cells (Lane 2) and HeLa cells (Lane 3), using ERAB antiobdy. The lane on the left is treated with systhesized peptide.
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Наименование: HSD17B10 Antibody.