FHIT AntibodyСпецификация| Объем | 100 мкл | | Синонимы | AP3Aase, FRA3B, bis(5-adenosyl)-triphosphatase, inucleosidetriphosphatase, AP3A HYDROLASE FRAGILE SITE 3p14.2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P49789 | | Иммуноген | Synthesized peptide derived from human FHIT. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.<br/><br/>Hideshi Ishii, Cancer Res., Dec 2006, 66: 11287 - 11292.<br/>Francesca Bianchi, PNAS, Dec 2006, 103: 18981 - 18986.<br/>Koshi Mimori, Cancer Res., Mar 2006, 66: 2683 - 2690.<br/>Tamotsu Kuroki, Cancer Res., Jul 2003, 63: 3724 - 3728.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FHIT antibody.
 | Immunofluorescence analysis of A549 cells, using FHIT antibody.
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Наименование: FHIT Antibody.