FOS AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Cellular oncogene fos, FOS, G0/G1 switch regulatory protein 7, G0S7, Proto-oncogene protein c-fos | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P01100 | | Иммуноген | Synthesized peptide derived from human Fos. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.<br/><br/>Qi Mei, Am J Physiol Endocrinol Metab, Oct 2001, 281: E655 - E664.<br/>Jennifer R. Brown, Mol. Cell. Biol., Sep 1998, 18: 5609 - 5619.<br/>T K Kerppola, Mol. Cell. Biol., Jun 1993, 13: 3782 - 3791.<br/>L J Ransone, Genes & Dev., Jun 1989, 3: 770 - 781.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Fos antibody.
 | Western blot analysis of extracts from HepG2 cells, using Fos antibody.
 | Western blot analysis of extracts from A549 cells (Lane 2), Hela cells (Lane 3) and JK cells (Lane 4), using Fos antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: FOS Antibody.