FZD8 AntibodyСпецификация| Объем | 50 мкг | | Синонимы | Frizzled-8 (Fz-8) (hFz8), FZD8 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9H461 | | Иммуноген | Recombinant Human Frizzled-8 protein (55-233AA) | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IHC, Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200 | | Примечание | Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Frizzled-8 | | Области исследований | Others | | Ссылка на страницу на сайте производителя | ссылка | Western Blot
Positive WB detected in: Mouse heart tissue, Mouse liver tissue, Mouse lung tissue, Mouse kidney tissue
All lanes: FZD8 antibody at 2.7µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 74 kDa
Observed band size: 74 kDa
 | Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA880970LA01HU at dilution of 1:100
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Наименование: FZD8 Antibody.