Gabra3 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Gamma-aminobutyric acid receptor subunit alpha-3, Gabra3, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P20236 | | Иммуноген | Peptide sequence around aa. 33~37(R-R-Q-E-P)derived from Rat GABA A Receptor a3. | | Источник | Rabbit | | Видовая специфичность | Human, Rat, Mouse | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | GABA (g-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1).<br/><br/>Jones, K.A. et al. (2000) Neuropsychopharmacology 23, S41-9. <br/>Duthey, B. et al. (2002) J Biol Chem 277, 3236-41. <br/>Kaupmann, K. et al. (1997) Nature 386, 239-46. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide | | Области исследований | Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extract from rat brain and mouse brain tissue and C6 cells using GABA A Receptor a3 Antibody
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Наименование: Gabra3 Antibody.