GRK6 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | EC 2.7.11.16, G-protein-coupled receptor kinase 6, GPRK6, kinase GRK6, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P43250 | | Иммуноген | Synthesized peptide derived from N-terminal of human GRK6. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 | | Примечание | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis By similarity. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).<br/><br/>Benovic J.L., J. Biol. Chem. 268:19521-19527(1993).<br/>Haribabu B., Proc. Natl. Acad. Sci. U.S.A. 90:9398-9402(1993).<br/>Stoffel R.H., J. Biol. Chem. 269:27791-27794(1994). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Jurkat cells, COLO205 cells and HUVEC cells, using GRK6 antibody.
 | Immunofluorescence analysis of HeLa cells, using GRK6 antibody.
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Наименование: GRK6 Antibody.