HDAC3 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | HD3, RPD3, RPD3-2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O15379 | | Иммуноген | Peptide sequence around aa.420~424(N-D-K-E-S) derived from Human HDAC3. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation <br /><br />Wei L.-N., Hu X., Chandra D., Seto E., Farooqui M.J. Biol.Chem. 275:40782-40787(2000) <br />Li H., Leo C., Zhu J., Wu X., O'Neil J., Park E.-J., Chen J.D.Mol. Cell. Biol. 20:1784-1796(2000)</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cardiovascular,Metabolism,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Hela, K562 and 3T3 cells using HDAC3 Antibody.
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Наименование: HDAC3 Antibody.