LAIR1 Antibody, Biotin conjugated

Спецификация

Объем	50 мкг
Синонимы	Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305), LAIR1, CD305
Клональность	Polyclonal Antibody
Организм	Human
uniprot	Q6GTX8
Иммуноген	Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 protein (22-165AA)
Источник	Rabbit
Видовая специфичность	Human
Применение	ELISA
Примечание	Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Biotin
Буффер	Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Форма	Liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	>95%, Protein G purified
Области исследований	Immunology
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Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:	Антитела
	Объем:	50 мкг
	Кат. номер:	CSB-PA012721LD01HU
Цена (с НДС 20%):	по запросу	В корзину
Наименование: LAIR1 Antibody, Biotin conjugated. Примечание: дополнительная информация (на английском языке).