LAT (Ab-255) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | 36 kDa phospho-tyrosine adapter protein, 36 kDa phospho-tyrosine adaptor protein, LAT, LAT1, linker for activation of T cells | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O43561 | | Иммуноген | Synthesized non-phosphopeptide derived from human LAT around the phosphorylation site of tyrosine 255. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.<br/><br/>Zhang W., Cell 92:83-92(1998).<br/>Martin J., Nature 432:988-994(2004).<br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells, using LAT (Ab-255) antibody.
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Наименование: LAT (Ab-255) Antibody.