HNRNPA1 (Ab-192) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | HNRPA1, HNRPA1L3, hnRNP A1, hnRNP-A1, MGC102835 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P09651 | | Иммуноген | Peptide sequence around aa.190~194(S-S-S-Q-R)derived from Human hnRNP A1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts . hnRNP A1 regulates the alternative splicing of c-Src, c-H-Ras and modifies initiation of translation of the fibroblast growth factor 2 mRNA. hnRNP A1 expression level is elevated in many cancers, knockdown of hnRNP A1 leads to apoptosis in various cancer cells . Although predominantly nuclear, hnRNP A1 is continually transported from the nucleus to the cytoplasm where it disassociates from mRNA and is rapidly re-imported into the nucleus . hnRNP A1 binds to cis-acting repressive sequences (CRS) of HIV-1 to influence HIV-1 production . HIV-1 enhances hnRNP A1 expression and promotes the relocalization of hnRNP A1 to the cytoplasm ,<br/><br/>Myer, V.E. and Steitz, J.A. (1995) RNA 1, 171-82. <br/>Rooke, N. et al. (2003) Mol Cell Biol 23, 1874-84. <br/>Guil, S. et al. (2003) Mol Cell Biol 23, 2927-41. <br/>Bonnal, S. et al. (2005) J Biol Chem 280, 4144-53. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Microbiology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extract from 293 cells using hnRNP A1(Ab-192) Antibody.
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Наименование: HNRNPA1 (Ab-192) Antibody.