HSP90AB1 (Ab-254) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | HS90B, HSP 84, HSP90-beta, HSP90AB1, HSPC2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P08238 | | Иммуноген | Synthesized non-phosphopeptide derived from human HSP90B around the phosphorylation site of serine 254 (V-G-S(p)-D-E). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<br/><br/>Lothar Goretzki, AACR Meeting Abstracts, Apr 2006, 2006: 468.<br/>Jean-Fran ois Louvion, Mol. Biol. Cell, Nov 1998, 9: 3071.<br/>Angelika Lueking, Mol. Cell. Proteomics, Dec 2003, 2: 1342.<br/>Jason Fontana Circ, Res., May 2002, 90: 866.<br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HSP90B (Ab-254) antibody.
 | Immunofluorescence analysis of HeLa cells, treated with TNF-a (20nM, 15mins), using HSP90B (Ab-254) antibody.
 | Western blot analysis of extracts from Hela cells treated with TNF-? (20ng/ml, 30min), using HSP90B (Ab-254) antibody.
 | Western blot analysis of extracts from HeLa cells (Lane 2), CoLo cells (Lane 3), HepG2 cells (Lane 4) and 293 cells (Lane 5), using HSP90B (Ab-254) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: HSP90AB1 (Ab-254) Antibody.