| Объем | 100 мкл |
| Синонимы | MEAI, Menin, SCG2, Wermer syndrome, Zollinger-Ellison syndrome |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | O00255 |
| Иммуноген | Synthesized peptide derived from internal of human MEN1. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 |
| Примечание | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression By similarity. May be involved in DNA repair.<br/><br/>Chandrasekharappa S.C., Science 276:404-407(1997).<br/>Jin S., Cancer Res. 63:4204-4210(2003).<br/>Schnepp R.W., Cancer Res. 64:6791-6796(2004).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HuvEc cells, using MEN1 antibody.
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MEN1 antibody.
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Наименование: MEN1 Antibody.