IGF1R (Ab-1346) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Insulin-like growth factor I receptor, CD221, IGF1R, kinase IGF1R, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P08069 | | Иммуноген | Peptide sequence around aa.1344~1348 (Q-P-Y-A-H) derived from Human IGF-1R . | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.<br/><br/>Adams, T.E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093<br/>Baserga, R. et al. (2000) Oncogene 19, 5574-5581<br/>Scheidegger, K.J. et al. (2000) J. Biol. Chem. 275, 38921-38928.<br/>O'Connor R, et al. Mol Cell Biol 1997 Jan, 17(1): 427-35<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cancer,Developmental biology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells using IGF-1R(Ab-1346) Antibody and the same antibody preincubated with blocking peptide.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IGF-1R(Ab-1346) Antibody(left) or the same antibody preincubated with blocking peptide(right).
 | | | |
Информация для заказа |
Наименование: IGF1R (Ab-1346) Antibody.