KMT2E AntibodyСпецификация| Объем | 50 мкл | | Синонимы | Inactive histone-lysine N-methyltransferase 2E (Inactive lysine N-methyltransferase 2E) (Myeloid/lymphoid or mixed-lineage leukemia protein 5), KMT2E, MLL5 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q8IZD2 | | Иммуноген | Recombinant Human Histone-lysine N-methyltransferase 2E protein (182-316AA) | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, Recommended dilution: WB:1:500-1:5000 | | Примечание | Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Histone-lysine N-methyltransferase 2E | | Области исследований | Epigenetics and Nuclear Signaling, Cancer, Developmental biology, Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western Blot
Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate, NIH/3T3 whole cell lysate, 293T whole cell lysate, MCF-7 whole cell lysate, K562 whole cell lysate
All lanes: KMT2E antibody at 3.1µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 205, 196, 69, 99, 186, 181, 201, 132 kDa
Observed band size: 80 kDa
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Информация для заказа |
Наименование: KMT2E Antibody.