LATS1/LATS2 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | EC 2.7.11.1, Large tumor suppressor 1, WARTS, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O95835/Q9NRM7 | | Иммуноген | Synthesized peptide derived from Internal of human LATS1/2. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, IHC,IHC:1:50-1:100 | | Примечание | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.<br/><br/>Tao W., Nat. Genet. 21:177-181(1999).<br/>Nishiyama Y., FEBS Lett. 459:159-165(1999).<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using LATS1/2 antibody.
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Наименование: LATS1/LATS2 Antibody.