LEF1 Antibody, FITC conjugatedСпецификация| Объем | 100 мкг | | Синонимы | Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha), LEF1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9UJU2 | | Иммуноген | Recombinant Human Lymphoid enhancer-binding factor 1 protein (75-216AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | FITC | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Lymphoid enhancer-binding factor 1 | | Области исследований | Epigenetics and Nuclear Signaling, Cancer, Developmental biology, Stem cells | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкг | | Кат. номер: | CSB-PA012856LC01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: LEF1 Antibody, FITC conjugated.
Примечание: дополнительная информация (на английском языке). |
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