NTRK1 (Ab-791) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth factor receptor, TRK, TRK1 transforming tyrosine kinase protein | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P04629 | | Иммуноген | Peptide sequence around aa.789~793 (P-V-Y-L-D) derived from Human TrkA. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, IF,IF:1:100-1:200 | | Примечание | Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.<br/><br/>Wiese S, et al. Proc Natl Acad Sci U S A. 2007 Oct 23, 104(43):17210-5.<br/>Valdez G, et al. Proc Natl Acad Sci U S A. 2007 Jul 24,104(30):12270-5<br/>Inoue K, et al. J Biol Chem. 2007 Aug 17,282(33):24175-84<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Others | | Ссылка на страницу на сайте производителя | ссылка | Immunofluorescence staining of methanol-fixed Hela cells using TrkA(Ab-791) Antibody.
 | | | |
Информация для заказа |
Наименование: NTRK1 (Ab-791) Antibody.