| Объем | 100 мкл |
| Синонимы | MAPT, Microtubule-associated protein tau, MTBT1, Neurofibrillary tangle protein, Paired helical filament-tau |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P10636 |
| Иммуноген | Synthesized non-phosphopeptide derived from human Tau around the phosphorylation site of serine 717/400 (V-V-S(p)-G-D). |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.<br/><br/>Goedert M.,Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988).<br/>Goedert M.,EMBO J. 8:393-399(1989).<br/>Lee G.,Neuron 2:1615-1624(1989).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Neuroscience,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from rat brain cells, using Tau (Ab-717/400) antibody.
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Наименование: MAPT (Ab-717/400) Antibody.