| Объем | 100 мкл |
| Синонимы | Activator-recruited cofactor 32 kDa component, ARC32, MED8, Mediator complex subunit 8, Mediator of RNA polymerase II transcription subunit 8 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q96G25 |
| Иммуноген | Synthesized peptide derived from Internal of human MED8. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.<br/><br/>Brower C.S., Proc. Natl. Acad. Sci. U.S.A. 99:10353-10358(2002).<br/>Gregory S.G., Nature 441:315-321(2006).<br/>Naeaer A.M., Nature 398:828-832(1999).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from Jurkat/K562 cells, using MED8 antibody.
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Наименование: MED8 Antibody.