MERTK/TYRO3 (Ab-753) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | c-mer, c-mer proto-oncogene tyrosine kinase, MER, MER receptor tyrosine kinase, MERTK | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q12866/Q06418 | | Иммуноген | Synthesized peptide derived from Internal of human MERTK. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | <p>Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.<br /><br />Graham D.K., Cell Growth Differ. 5:647-657(1994).<br />Gal A., Nat. Genet. 26:270-271(2000).<br />Ling L., J. Biol. Chem. 271:18355-18362(1996).</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Neuroscience,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 3T3 cells (Lane 2), using MER (Ab-753) antiobdy. The lane on the left is treated with synthesized peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA114581 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: MERTK/TYRO3 (Ab-753) Antibody.
Примечание: дополнительная информация (на английском языке). |
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