| Объем | 100 мкл |
| Синонимы | Minichromosome maintenance complex component 4 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P33991 |
| Иммуноген | Synthetic peptide of human MCM4 |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC,ELISA:1:1000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Примечание | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen affinity purification |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA232265(MCM4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ?200)
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The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA232265(MCM4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ?200)
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Gel: 8%SDS-PAGE, Lysate: 50 ?g, Lane 1-3: NIH/3T3 cells, Hela cells, K562 cells, Primary antibody: CSB-PA232265(MCM4 Antibody) at dilution 1/700, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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Наименование: MCM4 Antibody.