MRE11A AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Double-strand break repair protein MRE11A, MRE11 homolog 1, MRE11 meiotic recombination 11 homolog A, MRE11A, HNGS1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P49959 | | Иммуноген | Synthesized peptide derived from internal of human MRE11A. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.<br/><br/>Petrini J.H.J.,, Genomics 29:80-86(1995).<br/>Paull T.T., Mol. Cell 1:969-979(1998).<br/>Pitts S.A., Hum. Mol. Genet. 10:1155-1162(2001).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from RAW264.7 cells, HT-29 cells and LOVO cells, using MRE11A antibody.
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Наименование: MRE11A Antibody.