PDX1 AntibodyСпецификация| Объем | 50 мкл | | Синонимы | PDX-1,Glucose-sensitive factor,GSF,Insulin promoter factor 1,IPF-1,Insulin upstream factor 1,IUF-1,Islet/duodenum homeobox-1,
IDX-1,Somatostatin-transactivating factor 1,STF-1,PDX1,IPF1, STF1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P52945 | | Иммуноген | human PDX1 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC | | Примечание | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen Affinity purified | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cardiovascular,Developmental biology,Metabolism,Signal transduction,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | | | |
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Наименование: PDX1 Antibody.