| Объем | 100 мкг |
| Синонимы | Nucleoprotein (Nucleocapsid protein) (Protein N), N |
| Клональность | Polyclonal Antibody |
| Организм | Junin mammarenavirus |
| uniprot | P14239 |
| Иммуноген | Recombinant Junin mammarenavirus Nucleoprotein protein (1-564AA) |
| Источник | Rabbit |
| Видовая специфичность | Junin mammarenavirus |
| Применение | ELISA, WB, Recommended dilution: WB:1:500-1:5000 |
| Примечание | Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). Interacts with host IKBKE (via Protein kinase domain), the interaction inhibits IKBKE kinase activity. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | >95%, Protein G purified |
| Абревеатура | Nucleoprotein |
| Области исследований | Others |
| Ссылка на страницу на сайте производителя | ссылка |
Western Blot
Positive WB detected in Recombinant protein
All lanes: N antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
predicted band size: 64 kDa
observed band size: 64 kDa
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Наименование: N Antibody.