NDFIP1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Breast cancer-associated protein SGA-1M, MGC10924, N4WBP5, NDFIP1, Nedd4 family interacting protein 1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9BT67 | | Иммуноген | Synthesized peptide derived from C-terminal of human NDFIP1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation By similarity. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.<br/><br/>Petroziello J.M., Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.<br/>Matsuda A., Oncogene 22:3307-3318(2003).<br/>Otsuki T., DNA Res. 12:117-126(2005).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells, using NDFIP1 antibody.
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Наименование: NDFIP1 Antibody.