Phospho-DDIT3 (Ser30) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | C/EBP-homologous protein, DDIT3, GADD153, DNA-damage inducible transcript 3, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P35638 | | Иммуноген | Peptide sequence around phosphorylation site of serine30(V-L-S(p)-S-D) derived from Human CHOP . | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. <br/><br/>Ubeda M, Habener JF (2003) J Biol Chem 278, 40514-20 </p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser30 | | Области исследований | Epigenetics and Nuclear Signaling,Developmental biology,Metabolism,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Jurkat cells treated with PMA using Phospho-CHOP (Ser30) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA799326 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-DDIT3 (Ser30) Antibody.
Примечание: дополнительная информация (на английском языке). |
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