Phospho-MAPT (Ser416) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | MAPT, MTAPT, MTBT1, Neurofibrillary tangle protein, PHF-tau | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P10636 | | Иммуноген | Peptide sequence around phosphorylation site of serine 416 (T-G-S(p)-I-D) derived from Human Tau. | | Источник | Rabbit | | Видовая специфичность | Human, Rat, Mouse | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). <br /><br />Timm T, et al. (2003) EMBO J, 22(19): 5090-5101. ,</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser416 | | Области исследований | Neuroscience,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extract from rat brain, rat hippocampus and mouse brain using Tau(phospho-Ser416) Antibody.
 | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA050509 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-MAPT (Ser416) Antibody.
Примечание: дополнительная информация (на английском языке). |
|
