NPHP4 Antibody, HRP conjugated

Спецификация

Объем	50 мкг
Синонимы	Nephrocystin-4 (Nephroretinin), NPHP4, KIAA0673
Клональность	Polyclonal Antibody
Организм	Human
uniprot	O75161
Иммуноген	Recombinant Human Nephrocystin-4 protein (397-543AA)
Источник	Rabbit
Видовая специфичность	Human
Применение	ELISA
Примечание	Involved in the organization of apical junctions, the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	HRP
Буффер	Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Форма	Liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	>95%, Protein G purified
Абревеатура	Nephrocystin-4
Области исследований	Cell biology, Signal transduction
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Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:	Антитела
	Объем:	50 мкг
	Кат. номер:	CSB-PA015987LB01HU
Цена (с НДС 20%):	по запросу	В корзину
Наименование: NPHP4 Antibody, HRP conjugated. Примечание: дополнительная информация (на английском языке).