Phospho-NTRK1 (Tyr701) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | EC 2.7.10.1, High affinity nerve growth factor receptor precursor, kinase TrkA, NTRK1, p140-TrkA, Slow nerve growth factor receptor, TRK, Trk-A, TRK1 transforming tyrosine kinase protein, TRKA | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P04629 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 701 (I-L-Y(p)-R-K) derived from Human Trk A. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr701 | | Области исследований | Others | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from mouse brain cells, using Trk A (Phospho-Tyr701) antibody. The lane on the right is treated with the synthesized peptide.
 | Immunohistochemistry analysis of paraffin-embedded human brain tissue using Trk A (Phospho-Tyr701) antibody. The picture on the right is treated with the synthesized peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA830815 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-NTRK1 (Tyr701) Antibody.
Примечание: дополнительная информация (на английском языке). |
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