Phospho-SIRT1 (Ser47) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | hSIR2, hSIRT1, NAD-dependent deacetylase sirtuin 1, SIR1, SIR2L1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q96EB6 | | Иммуноген | Peptide sequence around phosphorylation site of serine 47(E-R-S(p)-P-G) derived from Human SirT1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. <br/><br/>Gao Z, et al. (2011) J Biol Chem 286, 22227-34. Zschoernig B, Mahlknecht U (2009)Biochem Biophys Res Commun 381, 372-7. Nasrin N, et al. (2009)PLoS One 4, e8414.</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser47 | | Области исследований | Epigenetics and Nuclear Signaling,Cell biology,Tags & Cell Markers,Metabolism,Microbiology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from JK tissue using SirT1 (Phospho-Ser47) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA857953 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-SIRT1 (Ser47) Antibody.
Примечание: дополнительная информация (на английском языке). |
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