NR3C1 (Ab-226) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | GCR, GRL, GRL1, NR3C1, glucocorticoid receptor | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P04150 | | Иммуноген | Synthesized non-phosphopeptide derived from human GR around the phosphorylation site of serine 226/234/246 (L-L-S-P-L). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.<br/><br/>Kyung Jin Kwak, J. Exp. Bot., Nov 2005, 56: 3007 - 3016. <br/>Maite de Llanos, Hum. Reprod., Jan 2005, 20: 216 - 220. <br/>M. Lynch, Mol. Hum. Reprod., Jul 2005, 11: 507 - 512. <br/>Valeriya P. Makarenkova, J. Immunol., Feb 2006, 176: 2085 - 2094.<br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human brain tissue using GR (Ab-226) antibody.
 | Western blot analysis of extracts from Jurkat cells, treated with EGF (200ng/ml, 15mins), using GR (Ab-226) antibody.
 | Western blot analysis of extracts from JK cells (Lane 2) and K562 cells (Lane 3), using GR(Ab-226) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: NR3C1 (Ab-226) Antibody.