PCNA Antibody, Biotin conjugatedСпецификация| Объем | 50 мкг | | Синонимы | Proliferating cell nuclear antigen (PCNA) (Cyclin), PCNA | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P12004 | | Иммуноген | Recombinant Human Proliferating cell nuclear antigen protein (1-261AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Biotin | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Proliferating cell nuclear antigen | | Области исследований | Isotype/Loading Controls, Epigenetics and Nuclear Signaling, Cancer, Cell biology, Tags & Cell Markers | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 50 мкг | | Кат. номер: | CSB-PA01567D0Rb | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: PCNA Antibody, Biotin conjugated.
Примечание: дополнительная информация (на английском языке). |
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