PPP1CA Antibody, Biotin conjugatedСпецификация| Объем | 50 мкг | | Синонимы | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16), PPP1CA, PPP1A | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P62136 | | Иммуноген | Recombinant Human Serine/threonine-protein phosphatase PP1-alpha catalytic subunit protein (192-330AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Biotin | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | | Области исследований | Cancer, Metabolism, Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 50 мкг | | Кат. номер: | CSB-PA018503LD01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: PPP1CA Antibody, Biotin conjugated.
Примечание: дополнительная информация (на английском языке). |
|
