Phospho-APP (Thr743/668) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | A4, AD1, APP, APPI, Beta-amyloid protein 42 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P05067 | | Иммуноген | Peptide sequence around phosphorylation site of threonine743 /668 (A-V-T(p)-P-E) derived from Human Amyloid beta A4. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200 | | Примечание | <p>Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity By similarity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. <br/><br/>Ming-Sum Lee J. Cell Biol., Oct 2003, 163: 83.<br />Tadashi Nakaya and Toshiharu Suzuki Genes Cells, Jun 2006, 11: 633 - 645<br />Keun-A Chang, Mol. Cell. Biol., Jun 2006, 26: 4327 篓C 4338.<br />Thor D. Stein J. Neurosci., Sep 2004, 24: 7707 - 7717<br /></p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Thr743/668 | | Области исследований | Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from cos-7 cells (Lane 2), using Amyloid ? A4 (Phospho-Thr743/668) Antibody. The lane on the left is treated with antigen-specific peptide.
 | Immunohistochemical analysis of paraffin-embedded human brain tissue using Amyloid ? A4 (phospho-Thr743/668) antibody (left)or the same antibody preincubated with blocking peptide (right).
 | Immunofluorescence staining of methanol-fixed HeLa cells using Amyloid ? A4 (phospho-Thr743/668) Antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA212801 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-APP (Thr743/668) Antibody.
Примечание: дополнительная информация (на английском языке). |
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