Phospho-APP (Thr668) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | AAA, AD1, PN2, ABPP, APPI | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P05067 | | Иммуноген | Peptide sequence around phosphorylation site of threonine 668 (A-V-T(p)-P-E) derived from Human APP. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. <br /><br />Hung, A.Y. and Selkoe, D.J. (1994) EMBO J. 13, 534-542. <br />Suzuki, T. et al. (1994) EMBO J. 13, 1114-1122 <br />Ando, K. et al. (1999) J. Neurosci. 19, 4421-4427. <br />Iijima, K.I. et al. (2000) J. Neurochem. 75, 1085-1091</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Thr668 | | Области исследований | Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from mouse brain tissue using APP(Phospho-668) Antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).
 | Western blot analysis of extracts from Hela cells, treated with Noc or calf intestinal phosphatase (CIP), using APP (Phospho-Thr668) Antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA296382 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-APP (Thr668) Antibody.
Примечание: дополнительная информация (на английском языке). |
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