| Объем | 100 мкл |
| Синонимы | ERBB1, Receptor protein-tyrosine kinase ErbB-1, kinase EGFR |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P00533 |
| Иммуноген | Peptide sequence around phosphorylation site of tyrosine 1172 (P-D-Y(p)-Q-Q) derived from Human EGFR. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:100 |
| Примечание | Receptor for EGF, but also for other members of the EGF family, as TGF-a, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.<br/><br/>Noguchi T, et al. (1994) Mol Cell Biol 14(10): 6674-6682<br/>Doherty JK, et al. (1999) Proc Natl Acad Sci U S A 96(19): 10869-10874<br/>Kanner SB, et al. (1991) Mol Cell Biol 11(2): 713-720<br/>Wu TT, et al. (1998) Mol Biol Cell 9(7): 1661-1674<br/>O |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Tyr1172 |
| Области исследований | Cancer,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from A431 cells untreated or treated with EGF using EGFR(Phospho-Tyr1172) Antibody.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EGFR(Phospho-Tyr1172) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: Phospho-EGFR (Tyr1172) Antibody.