Phospho-GRIN1 (Ser890) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | GLURZ1, GRIN1, N-methyl-D-aspartate receptor, NMZ1, NMDZ1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q05586 | | Иммуноген | Peptide sequence around phosphorylation site of serine890(A-S-S(p)-F-K) derived from Human NMDAR1 . | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.<br/><br/>Xu M, Smothers CT, Woodward JJ (2011) Alcohol 45, 373-80. Kong M, Ba M, Song L, Liu Z (2009)Neurochem Res 34, 1513-21 . Jackson MF, et al. (2006)J Neurochem 96, 1509-18.</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser890 | | Области исследований | Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from A549 tissue using Phospho-NMDAR1 (Ser890) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA239875 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-GRIN1 (Ser890) Antibody.
Примечание: дополнительная информация (на английском языке). |
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