Phospho-HDAC1 (Ser421) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | HD1, RPD3, GON-10, RPD3L1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q13547 | | Иммуноген | Peptide sequence around phosphorylation site of Serine 421(E-F-S(p)-D-S) derived from Human HDAC1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser421 | | Области исследований | Isotype/Loading Controls,Epigenetics and Nuclear Signaling,Cardiovascular,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HepG2 cells using HDAC1 (Phospho-Ser421) Antibody.The lane on the left is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA599472 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-HDAC1 (Ser421) Antibody.
Примечание: дополнительная информация (на английском языке). |
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