PTK2 (Ab-861) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FADK 1, FAK1, PTK2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q05397 | | Иммуноген | Peptide sequence around aa. 859~863 (H-I-Y-Q-P) derived from Human FAK. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.<br/><br/>Shi Q, et al. (2003) Mol Biol Cell, 14(10): 4306-15.<br/>Vadlamudi RK, et al. (2003) FEBS Lett, 543(1-3): 76-80.<br/>Eliceiri BP, et al. (2002) J Cell Biol Apr 01, 157(1): 149-60.<br/>Abu-Ghazaleh R, (2001) et al. Biochem J, 360(Pt 1): 255-64.<br/>Slack JK, et al.(2001) Oncogene, 20(10): 1152-63.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Cancer,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HT29, Hela and 293 cells using FAK(Ab-861) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using FAK(Ab-861) Antibody(left) or the same antibody preincubated with blocking peptide(right).
 | | | |
Информация для заказа |
Наименование: PTK2 (Ab-861) Antibody.