PTTG1 Antibody, Biotin conjugated

Спецификация

Объем	50 мкг
Синонимы	Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG), PTTG1, EAP1 PTTG TUTR1
Клональность	Polyclonal Antibody
Организм	Human
uniprot	O95997
Иммуноген	Recombinant Human Securin protein (2-202AA)
Источник	Rabbit
Видовая специфичность	Human
Применение	ELISA
Примечание	Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Biotin
Буффер	Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Форма	Liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	>95%, Protein G purified
Абревеатура	Securin
Области исследований	Epigenetics and Nuclear Signaling, Cancer, Cell biology
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Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:	Антитела
	Объем:	50 мкг
	Кат. номер:	CSB-PA019074LD01HU
Цена (с НДС 20%):	по запросу	В корзину
Наименование: PTTG1 Antibody, Biotin conjugated. Примечание: дополнительная информация (на английском языке).